Tableting machine refers to a machine that presses a pellet or a powdered material into a die hole and presses a tablet into a tablet. In the pharmaceutical process of Chinese and Western medicine, the tablet press is one of the essential equipment. In recent years, the problem of environmental pollution in China has become increasingly prominent. GMP standards have also been continuously improved. While the tablet press equipment is facing an upgrade and transformation, the types of tablet presses emerging in the market are becoming more and more diverse, such as single-punch tablet presses. , basket type tablet presses, rotary tablet presses, etc. These devices have different functions to meet the needs of different industry tablets.
However, during the use of the tablet press, there are often cases where the user reports that the result of the tableting is not smooth. For example, in recent days, pharmaceutical companies have indicated that the company's equipment for producing tablets is not very useful, and there is a phenomenon of tablet falling off. What is the situation?
A technician at a tablet press manufacturer said that the phenomenon of shedding of the tablet after it was pushed out of the die hole was called a split. Sometimes the middle split of the tablet is divided into two pieces, but this rarely happens. In this regard, the technicians analyzed the causes of the splitting phenomenon for several reasons, and the author has sorted out the content.
Reason one: too much fine powder in the granules
According to reports, the reason for the rupture of the tablet press during the tableting process is that the fine powder in the granules is too much, resulting in the air not escaping during compression, the compression speed is too fast, and the gap between the punch and the die hole is relatively small. The air is enclosed in the tablet, and the air begins to swell after the pressure has passed, which causes the lobulation phenomenon to occur.
In this case, the fine powder in the granules should be removed so that the air in the tablet can escape.
Reason 2: Improper compression behavior
Improper behavior of particle compression can easily cause uneven pressure during pressing. Because of the strong elasticity of the granules, slivers are produced during compression of the tablets, and the elastic recovery rate of the tablets after compression is relatively high.
Reason 3: The particles are too dry
Too dry particles can also cause lobes, and we should adjust the water content to prevent lobes.
Reason 4: Excessive pressure
If the pressure is too high, it will lead to splitting. In this case a split occurs and we can properly reduce the pressure to prevent it from splitting.
The technicians said that the pressure of different tablet press equipment is different. Among them, the single punching machine presses the tablet when it is unilateral pressure. When the rotary tablet press presses the sheet, it is pressed up and down. The elastic recovery rate is related to the pressure. The upper surface of the tablet is pressed for a short time. So first lobes from the top.
Knowing this, you can guide how to prevent the occurrence of splitting. For example, you can adjust the prescription design, increase the plasticity of raw materials and accessories, and improve the compression molding time of particles.
Reducing the pressure during compression also prevents cracking. Because the small elastic recovery ratio of the pressure becomes smaller, the water content in the pellets appropriately increases the plasticity of the pellets to improve the pressure distribution and prevent the cracks.
In addition, the skilled person suggests that lubricants or flow aids can also be added as appropriate.
In addition to the above reasons, there may be other causes of cracks, such as die hole deformation, and machine wear can also cause tablet lobes. The technicians said that if the common faults are eliminated after a common problem, it is recommended to contact the tablet press manufacturer for after-sales service and ask the professional to carry out the repair.
However, during the use of the tablet press, there are often cases where the user reports that the result of the tableting is not smooth. For example, in recent days, pharmaceutical companies have indicated that the company's equipment for producing tablets is not very useful, and there is a phenomenon of tablet falling off. What is the situation?
A technician at a tablet press manufacturer said that the phenomenon of shedding of the tablet after it was pushed out of the die hole was called a split. Sometimes the middle split of the tablet is divided into two pieces, but this rarely happens. In this regard, the technicians analyzed the causes of the splitting phenomenon for several reasons, and the author has sorted out the content.
Reason one: too much fine powder in the granules
According to reports, the reason for the rupture of the tablet press during the tableting process is that the fine powder in the granules is too much, resulting in the air not escaping during compression, the compression speed is too fast, and the gap between the punch and the die hole is relatively small. The air is enclosed in the tablet, and the air begins to swell after the pressure has passed, which causes the lobulation phenomenon to occur.
In this case, the fine powder in the granules should be removed so that the air in the tablet can escape.
Reason 2: Improper compression behavior
Improper behavior of particle compression can easily cause uneven pressure during pressing. Because of the strong elasticity of the granules, slivers are produced during compression of the tablets, and the elastic recovery rate of the tablets after compression is relatively high.
Reason 3: The particles are too dry
Too dry particles can also cause lobes, and we should adjust the water content to prevent lobes.
Reason 4: Excessive pressure
If the pressure is too high, it will lead to splitting. In this case a split occurs and we can properly reduce the pressure to prevent it from splitting.
The technicians said that the pressure of different tablet press equipment is different. Among them, the single punching machine presses the tablet when it is unilateral pressure. When the rotary tablet press presses the sheet, it is pressed up and down. The elastic recovery rate is related to the pressure. The upper surface of the tablet is pressed for a short time. So first lobes from the top.
Knowing this, you can guide how to prevent the occurrence of splitting. For example, you can adjust the prescription design, increase the plasticity of raw materials and accessories, and improve the compression molding time of particles.
Reducing the pressure during compression also prevents cracking. Because the small elastic recovery ratio of the pressure becomes smaller, the water content in the pellets appropriately increases the plasticity of the pellets to improve the pressure distribution and prevent the cracks.
In addition, the skilled person suggests that lubricants or flow aids can also be added as appropriate.
In addition to the above reasons, there may be other causes of cracks, such as die hole deformation, and machine wear can also cause tablet lobes. The technicians said that if the common faults are eliminated after a common problem, it is recommended to contact the tablet press manufacturer for after-sales service and ask the professional to carry out the repair.
On the basis of international cutting edge brush making technology and our own patented inventions, Haixing brush machines are stable and reliable and have been well accepted by the markets. These flat brush making machines have the functions of drilling holes, tufting, trimming and flagging the fibers. They are suitable to produce flat brushes, with high speed, low failure rate, and high production output. Flat brushes include washing brushes, nail brushes, shoe brushes, elevator brushes, and so on.
Flat Brush Machine, Flat Brush Making Machine, Washing Brush Making Machine, Shoe Brush Machine, Nail Brush Machine
Yangzhou Haixing CNC Brush Machine Co., Ltd. , https://www.brushmachine.nl