Researchers have discovered that 3 drugs have a good inhibitory effect on the new coronavirus

[ Instrument Network Instrument R & D ] On January 28, a series of good news came from the Wuhan Institute of Virology, Chinese Academy of Sciences: the institute has just developed antibody test strips for research; at the same time, the institute and the Academy of Military Medical Sciences have researched toxic drugs The team found that Remidiv or Remdesivir (GS-5734), Chloroquine (Sigma-C6628), Lee, which have a better inhibitory effect on the new coronavirus (2019-nCoV) at the cellular level. Three "old drugs" such as Ritonavir. Its subsequent clinical use is undergoing related procedures for approval.

Chloroquine has been used clinically since -1944; it was initially used to treat malaria, and its use has gradually expanded since then. In 1951, it was used to treat chloroquine rheumatoid arthritis with certain effects.

Ritonavir is an effective oral inhibitor of human immunodeficiency virus-1 (HIV-1) and human immunodeficiency virus-2 (HIV-2) aspartic proteases, blocking the enzyme and promoting the production of morphologically mature HIV particles The required polyprotein keeps the HIV particles in an immature state, thereby slowing the spread of HIV in the cells, preventing a new round of infection and delaying the development of the disease. Ritonavir is generally effective for zidovudine-sensitive and zidovudine and saquinavir-resistant HIV strains.

On January 21, according to the urgent scientific and technological needs of rapid epidemic management and emergency response, the Hubei Provincial Department of Science and Technology launched the "2019 New Pneumonia Emergency Science and Technology Research Project", established a new type of pneumonia emergency scientific research research group, and quickly advanced Related research work. The Scientific Research Group of the Pneumonia Prevention and Control Headquarters of Hubei Province New Coronavirus Infection organized a strong team in the province in several related fields such as virology and epidemiology, led by the Wuhan Institute of Virology of the Chinese Academy of Sciences, focusing on "rapid detection technology products Emergency research has been initiated in five areas, including R & D, the law of disease occurrence, development, and outcome, and clinical diagnosis and treatment, antiviral emergency drugs and vaccines, animal traceability research, and etiology and epidemiology research. With a view to carrying out epidemiological investigation and etiology traceability as soon as possible, revealing the mechanisms and rules of inflammatory response caused by pathogen infection as soon as possible, providing the foundation for disease treatment and drug development as soon as possible, and forming the ability to quickly detect and respond to new-type coronavirus as soon as possible.

Coronavirus infections are distributed in many regions of the world. China and the United Kingdom, the United States, Germany, Japan, Russia, Finland, India and other countries have found the presence of the virus. The infection caused by the virus occurs mainly in winter and early spring. In a home test in Michigan, USA, it was proved that coronavirus can infect all age groups, 29.2% are 0 to 4 years old, and 22% are over 40 years old. This is not the same as the epidemic situation of other upper respiratory viruses, such as respiratory syncytial virus, which mostly decrease in incidence with age. In addition, rhinoviruses are not common when the coronavirus is circulating.

At present, the Ministry of Science and Technology is organizing scientific and technological research on the diagnosis and treatment of new pneumonia. The emergency science and technology research project initiated by Hubei Province is very timely. The scientific research and research system on the diagnosis and treatment of new pneumonia has been formed with the emergency research on new pneumonia diagnosis and treatment carried out by the Ministry of Science and Technology.

Source: Hubei Daily, Chinese Academy of Sciences